Mostly Microbes and Infection - by David Ojcius

Cyclic exposure to the biocide DEAPA selects Salmonella Typhimurium variants with sharply increased tolerance to disinfection, heat, and gentamicin. Adaptive evolution produced multidrug‑tolerant strains carrying mutations across metabolic, signaling, transport, and motility genes, revealing broad cellular rewiring and highlighting risks for food‑processing sanitation.

Phylogeny strongly constrains glycoside hydrolase multidomain architecture across bacterial genera, while environmental factors fine‑tune domain organization in cosmopolitan lineages. Analysis of 158k GH proteins using domain‑adjacency networks reveals conserved lineage‑specific patterns and highlights accessory domains as key drivers of microbial functional adaptation.