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Endogenous hydrogen sulfide reprograms mitochondrial respiration and modulates pathogenicity in Ustilago maydis

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Highlights • Respiratory growth with cysteine increases H 2 S production in U. maydis. • Endogenous H 2 S promotes mitochondrial biogenesis and metabolic remodeling . • H 2 S shifts respiration toward alternative oxidase-dependent electron transport . • Elevated H 2 S increases global protein S-sulfenylation and S-persulfidation. • Endogenous H 2 S modulates disease severity during maize infection.