Mostly Microbes and Infection

D EMENTIA IS tragically  common among the elderly. In 2021 57m people worldwide were thought to have the condition. Ageing is a risk factor for many other ailments too, ranging from chronic inflammation to a decline in organ function. A growing body of work, however, suggests that simply taking a course of the shingles vaccine can meaningfully slow the decline. The new data, from a range of countries, suggests that it cuts risk by 20%.

  Highlights • Administration of the bacteriophage cocktail at a high MOI reduced APEC-induced morbidity and mortality by 20-30% in laying hens, validating its potential as an antimicrobial alternative. • The oral route (drinking water) demonstrated superior therapeutic efficacy compared to intramuscular injection, resulting in the complete absence of macroscopic lesions and a noticeable reduction in median histopathological scores, particularly in the spleen. • The administered phage cocktail achieved effective lytic activity against APEC and was recovered across multiple tissues without causing collateral damage or altering the general bacterial structure of the cecal microbiota.

A  sexually transmitted infections   ( STI ) is a   disease   which   spreads   by having   sex . STIs can spread through   oral sex   or   anal sex , or when two people's   genitals   touch. STIs can be caused by  viruses ,  bacteria , or  parasites . Examples of the most common STIs are listed on this page. Types of STDs

  Highlights • Meta-analysis of 11,115 gut metagenomes links uncultured species to human health • Healthy individuals show enrichment and greater diversity of uncultured bacteria • The genus CAG-170 contains uncultured taxa with the strongest health signatures • CAG-170 is ecologically important in healthy populations

  Highlights • Severe IAV infection imparts a long-lasting decline in cardiac function • Atypical GMP-independent CD319 +  pro-DC3s transport infectious IAV to cardiomyocytes • Direct IFN-I signaling on cardiomyocytes drives cardiac dysfunction • mod-mRNA delivery of dominant-negative IFNAR1 on cardiomyocytes ameliorates damage

  Highlights • Three NlpC/P60 endopeptidases identified in  Deinococcus radiodurans • CwlA is essential for cell viability and cell wall integrity • CwlB is involved in cell septation whereas CwlC is dispensable • Regulatory link between CwlA expression and the genotoxic stress response pathway