Posts

Editorial for special issue “Microorganisms and food security under climate change scenarios: from taxonomy to host–microbe interactions”

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  Highlights • Climate change and environmental stressors are major drivers affecting global food security and agricultural sustainability. • Microbial communities play a central role in nutrient cycling, plant health, and ecosystem resilience. • Climate variability alters microbial diversity, functions, and plant–microbe interactions. • Beneficial microorganisms enhance crop tolerance to abiotic and biotic stresses. • Microbiome-based strategies offer sustainable alternatives to chemical inputs in agriculture. • Advances in microbial genomics enable the exploration and application of microbial diversity. • Biological control agents represent eco-friendly solutions for plant disease management. • Integrating microbial taxonomy, ecology, and biotechnology is key to climate-resilient food systems.
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Childhood immunological imprinting of cross-subtype antibodies targeting the hemagglutinin head domain of influenza viruses

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  Highlights • H1/H3 cross-reactive head antibodies were isolated after seasonal flu vaccination • These cross-subtype antibodies target a conserved HA epitope involving residue 145 • Antibodies targeting this epitope were enriched in people born in the 1990s • H1N1s recently acquired a substitution that abrogated binding of these antibodies
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Evolutionary Conservation, Expansion and Diversification of Interferon stimulated genes (ISG) in Vertebrates: insights from fish

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  Highlight • This review examines the evolutionary origin, regulation, and functional diversification of IFN stimulated genes in vertebrates. Evolutionary pathways of IGS, with gene gain and loss, and their connection with redundancy and robustness are discussed.
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Vaginal microbiota transfer ameliorates cesarean-associated neurodevelopmental deficits in mice via N-bc2S1P synthesis on neonatal skin

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  Highlights • VMT restores skin  N -bc2S1P linked to early neurodevelopment in cesarean-born neonates • N -bc2S1P engages β-arrestin1-biased S1PR2 signaling in forebrain excitatory neurons • β-arrestin1-biased S1PR2 signaling recruits AP-1/CBP to increase Notch H3K27ac • Engineered  S. epidermidis  sustains  N -bc2S1P and extends rescue of CS-associated deficits
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Probiotic-driven microbiome remodeling is associated with coordinated immune and metabolic responses, improving growth and disease resistance in farmed tongue sole (Cynoglossus semilaevis)

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  Highlights • A probiotic-integrated semi-closed RAS protocol significantly improved growth (+0.08%/day) and survival (+6.9%) in Cynoglossus semilaevis. • Probiotic treatment reshaped the gut microbiota from Vibrio dominance to a Photobacterium-enriched community and altered quorum sensing pathways. • Metagenomics revealed enhanced CAZyme activity and nutrient metabolism potential in the probiotic group. • Multi-tissue transcriptomics demonstrated coordinated immune activation (NF-κB, IgA network) and JAK–STAT-mediated metabolic reprogramming. • Functional validation of ccl19 confirmed enhanced resistance against Vibrio harveyi, supporting an immune–metabolic crosstalk model.
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Targeting the US21 viroporin of human cytomegalovirus by calcium channel blockers as a new antiviral strategy

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  Highlights • CCBs bind the inner pore of the HCMV US21 viroporin and abolish pUS21-mediated ER Ca 2+  leakage. • CCBs inhibit HCMV replication. • CCBs prevent the cytobiological consequences of pUS21 expression. • CCBs treatment restores ER Ca 2+  levels to those of control cells. • CCBs do not affect basal intracellular Ca 2+  homeostasis.
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Predicting competition and substrate preferences for targeted microbiome alteration

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  Highlights • Translation measurements reveal how microbes allocate resources in communities • Functional profiles predict microbial competition and niche allocation • Predictions enable rational design of prebiotic and probiotic interventions • Interventions enable targeted modulation of complex microbiomes  in vitro  and  in vivo
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