Mostly Microbes and Infection

La   història dels tractaments dentals   es remunta a milers d'anys.   L'abast d'aquest article es limita a la   història   anterior a 1981.

  Highlights • Bacteria trigger extracellular alkalinization to prime defenses in uninfected tissues • CPKs phosphorylate and inhibit plasma membrane proton pumps to induce alkalinization • Alkaline pH sensitizes perception and production of the phytocytokines Peps and SCOOPs • Phytocytokines and alkalinization jointly propagate to promote cell-cell communication

  Highlights • Dietary variables had the largest effect on microbiota composition • Rustic and conventional rearing conditions led to differential microbiota profiles • Rustic rearing favoured  Treponema -enriched, more-diverse microbial profiles • Enterotypes were associated with husbandry conditions and faecal water content • Underexplored taxa contributed to  in vitro  fibre fermentation and SCFA production

  Highlights • Most mutations occurred in genes associated with WTA glycosylation. • All mutants exhibited impaired P100 phage binding. • Gene mutation patterns appeared serovar-dependent. • Serovar 4b-derived mutants showed greater fitness loss than 2a or 2b. • Phage-resistance induction led to increased antibiotics sensitivity.

  Highlights • E. bolteae  is enriched in HCC patient feces and correlates with poor prognosis • E. bolteae  translocates to the liver and promotes the progression of HCC • E. bolteae  surface protein PbpT subverts DSG1 function, thereby activating MAPK signaling • Neutralizing antibodies against PbpT suppress tumor growth in murine models

  Highlights • Virome functions as an independent regulator of small intestinal nutrient sensing • Virome elicits distinct responses across different intestinal cell types • Virome regulation of carbohydrate sensing depends on immune surveillance