Posts

How Bacterial Neurotoxins Drive Disease and Bioengineering Innovation

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Highlights • This review provides a mechanistic classification of bacterial neurotoxins. • Neurotoxins are discussed as modulators of neural and neuroimmune networks. • Emerging links between bacterial neurotoxins and the gut–brain axis are highlighted. • The role of neurotoxins in neurodegenerative disorders is critically evaluated. • Engineered neurotoxin platforms show promise for targeted neural therapeutics. • Current translational opportunities and limitations in precision neurology are reviewed.
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How Maternal Vitamin B12 Deficiency Drives Offspring Obesity via Bifidobacterium

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Highlights • Maternal vitamin B12 deficiency aggravates offspring obesity • Vitamin B12 deficiency reduces B. pseudolongum in dams and offspring • Loss of B. pseudolongum during lactation worsens obesity in offspring • Restoring B. pseudolongum or acetate alleviates this obesity via Ffar2-Ehhadh
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How Viral Proteases Trigger Lytic Cell Death for Universal mRNA Therapy

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Highlights • Engineered GSDMs are tailored as VIDAs to sense viral protease • VIDA is inert without infection and has potent antiviral effects in vitro and in vivo • VIDA elicits a “kill-and-alert” antiviral immune response in mice • AI-driven accelerated evolution generates safer and more potent VIDAs
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How to Disentangle Specific vs Non-Specific Transcriptomic Responses in Yeast

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Highlights • Bulk meta-transcriptomics separates recurrent and condition-specific responses. • Heat ramp triggers a broader, more structured program than heat shock. • WGCNA, GO and motif analyses identify recurrent non-specific modules. • Heat ramp-specific signatures link ribosome biogenesis and proteostasis. • Stress-responsive modules show limited overlap with evolutionarily young genes.
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How Seed Bacterial Microbiota Shapes Community Assembly and Crop Engineering

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Highlights • Seeds can transmit a subset of associated bacteria to the next plant generation. • Seed-associated bacteria can influence germination, nutrient acquisition, and pathogen suppression. • Seed-focused SynComs enable tests of bacterial persistence, seed-to-seedling transfer and effects on crop traits.
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Nipah Virus Vaccine Progress: Current Advances and Research Limitations

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Highlights • NiV as a highly pathogenic zoonotic agent, poses a persistent and severe threat to global public health. • This review systematically reviews the viral structure and pathogenic mechanisms of NiV. • This review summarizes the progress and breakthroughs in vaccine development and addresses current research limitations. • The review provides theoretical support for the precise prevention and control of NiV.
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How the Fish Gut-Water Interface Spreads Antibiotic Resistance Genes (ARGs)

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Highlights • Pristine river ecosystem hosts ESBL ARGs, like bla TEM and bla CTX-M . • The Yamuna River hosts multidrug, fluoroquinolone, fosfomycin, and β-lactam resistance genes. • Predominance of biofilm-forming bacteria and their co-occurrence with the ARGs.
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