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Cross-cohort meta-analysis reveals conserved gut microbiome signatures of insomnia

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  HIGHLIGHTS • Cross-cohort meta-analysis reveals reproducible gut microbiome signatures of insomnia • Eight conserved gut taxa are consistently associated with insomnia across studies • A small number of gut microbes drive most insomnia-associated functional shifts • The Burkholderia - Caballeronia-Paraburkholderia (BCP) complex drives key functions • Microbial metabolic changes may indirectly shape host immune and neural states
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Microbial metabolism of food allergens determines the severity of IgE-mediated anaphylaxis

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  Highlights • Human saliva and small intestine harbor peanut (PN) allergen-degrading bacteria • Microbes degrade immunodominant PN allergens, reducing IgE binding • Microbial PN metabolism alters allergen absorption, mast cell activity, and anaphylaxis • PN-degrading  Rothia  abundance is linked to higher PN threshold in patients
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Història de l'odontologia

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La   història dels tractaments dentals   es remunta a milers d'anys.   L'abast d'aquest article es limita a la   història   anterior a 1981.
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A regulatory network promotes apoplastic alkalinization to prime plant immunity in tissues distal to site of infection

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  Highlights • Bacteria trigger extracellular alkalinization to prime defenses in uninfected tissues • CPKs phosphorylate and inhibit plasma membrane proton pumps to induce alkalinization • Alkaline pH sensitizes perception and production of the phytocytokines Peps and SCOOPs • Phytocytokines and alkalinization jointly propagate to promote cell-cell communication
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From Forest to Farm: The Impact of a Broad Spectrum of Lifestyles on the Porcine Gut Microbiota

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  Highlights • Dietary variables had the largest effect on microbiota composition • Rustic and conventional rearing conditions led to differential microbiota profiles • Rustic rearing favoured  Treponema -enriched, more-diverse microbial profiles • Enterotypes were associated with husbandry conditions and faecal water content • Underexplored taxa contributed to  in vitro  fibre fermentation and SCFA production
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Phage P100 resistance in clinical and foodborne Listeria monocytogenes isolates is associated with adsorption-inhibiting mutations and fitness trade-offs

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  Highlights • Most mutations occurred in genes associated with WTA glycosylation. • All mutants exhibited impaired P100 phage binding. • Gene mutation patterns appeared serovar-dependent. • Serovar 4b-derived mutants showed greater fitness loss than 2a or 2b. • Phage-resistance induction led to increased antibiotics sensitivity.
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Intratumoral bacterium Enterocloster bolteae promotes hepatocellular carcinoma progression by directly binding tumor cells

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  Highlights • E. bolteae  is enriched in HCC patient feces and correlates with poor prognosis • E. bolteae  translocates to the liver and promotes the progression of HCC • E. bolteae  surface protein PbpT subverts DSG1 function, thereby activating MAPK signaling • Neutralizing antibodies against PbpT suppress tumor growth in murine models
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