Posts

Dietary soy shapes the microbiome to induce commensal-specific T follicular helper cells and IgA production

Image
Highlights • Dietary soy enhances L. reuteri and M. intestinale colonization in the small intestine • Dietary soy promotes Tfh cell and IgA responses in the Peyer’s patches of weaning mice • L. reuteri provides cognate antigens, while M. intestinale drives IL-1β production • Soy-induced IgA is polyreactive and protects against Salmonella infection
Read more

Bacterial Warfare at the Molecular Level: Pseudoalteromonas sp. H2 Disrupts Vibrio splendidus Membrane Integrity via ClpP-CheW2 Regulation

Image
Highlights • CheW2 negatively regulated the expression of outer membrane proteins in V. splendidus • ClpP degraded CheW2 based on the recognization of its AA motif at the N terminal • Pseudoalteromonas sp. H2 attenuated the expression of clpP gene of V. splendidus AJ01
Read more

Multi-omics analysis-based insights into the microbial community composition and flavor development potentiality of different varieties of sorghum (Sorghum bicolor L. Moench) fermented into Sesame flavor Baijiu

Image
Highlights • Sesame-flavor Baijiu fermentation was performed using different sorghum varieties. • Microbial interactions affected volatile formation differently in sorghum varieties. • Cultivar-specific physicochemical traits modulate microbial consortia structure. • Sorghum selection can format flavor paradigm and standardize Baijiu quality.
Read more

Metagenomic profiling of ocular surface microbiome alterations in patients with progressive supranuclear palsy-Richardson’s syndrome

Image
Highlights • This study systematically analyzed alterations in the ocular surface microbiome of patients with progressive supranuclear palsy-Richardson’s syndrome (PSP-RS) via metagenomic sequencing, with comparisons to Parkinson’s disease (PD) patients and healthy controls (HC). • The β-diversity of the ocular surface microbiome in PSP-RS patients was significantly altered compared to HC, while no such obvious difference was observed in PD patients. PSP-RS patients exhibited increased abundances of g_Acinetobacter and g_Anaerococcus, decreased abundance of g_Vibrio, as well as characteristic changes at the specific species (e.g., s_Acinetobacter_guillouiae) and strain levels. • The ocular surface microbiome of PSP-RS patients showed more significant remodeling in Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) functional pathways, involving multiple key pathways such as transposase activity and amino acid metabolism. • The abundance of g_Acinetobacter was positiv...
Read more

Manganese Homeostasis Supports Stenotrophomonas maltophilia Oxidative Stress Defense and Replication in Acanthamoeba castellanii Phagosomes

Image
Highlights • The  S. maltophilia  MntH importer contributes to H 2 O 2  resistance and intracellular survival • The Mn exporter MntP limits toxicity even at sub-inhibitory Mn²⁺ concentrations • The  S. maltophilia  MntR regulated genes include the extracytoplasmic TBDR-pTFP module • The TBDR-pTFP locus is specifically induced under combined Mn 2+  and Fe 2+  limitation • S. maltophilia  Mn homeostasis is linked to iron availability and oxidative stress responses
Read more

Bifidobacterium stercoris KC84 attenuates IBS-D-like symptoms via modulation of serotonin-related pathways and dendritic cell-mediated IFN-β induction

Image
Highlights • Bifidobacterium stercoris  KC84 alleviates IBS-D-like symptoms in mouse and rat models • KC84 modulates serotonin-related pathways associated with diarrhea • KC84 induces IFN-β production from colonic dendritic cells • IFN-β is associated with reduced intestinal smooth muscle contractility
Read more

Maternal helminths rewire the microbiota to promote offspring antiviral immunity

Image
Highlights • Maternal helminths promote offspring antiviral immunity via the microbiota • Helminth-altered microbiota produce IPA, which drives antiviral protection • IPA induces lung epithelial type I interferon responses to promote antiviral immunity • Helminth-endemic human microbiota are enriched in the tryptophan metabolism pathway
Read more