Història de l'odontologia
La història dels tractaments dentals es remunta a milers d'anys. L'abast d'aquest article es limita a la història anterior a 1981.
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A regulatory network promotes apoplastic alkalinization to prime plant immunity in tissues distal to site of infection
Highlights • Bacteria trigger extracellular alkalinization to prime defenses in uninfected tissues • CPKs phosphorylate and inhibit plasma membrane proton pumps to induce alkalinization • Alkaline pH sensitizes perception and production of the phytocytokines Peps and SCOOPs • Phytocytokines and alkalinization jointly propagate to promote cell-cell communication
From Forest to Farm: The Impact of a Broad Spectrum of Lifestyles on the Porcine Gut Microbiota
Highlights • Dietary variables had the largest effect on microbiota composition • Rustic and conventional rearing conditions led to differential microbiota profiles • Rustic rearing favoured Treponema -enriched, more-diverse microbial profiles • Enterotypes were associated with husbandry conditions and faecal water content • Underexplored taxa contributed to in vitro fibre fermentation and SCFA production
Phage P100 resistance in clinical and foodborne Listeria monocytogenes isolates is associated with adsorption-inhibiting mutations and fitness trade-offs
Highlights • Most mutations occurred in genes associated with WTA glycosylation. • All mutants exhibited impaired P100 phage binding. • Gene mutation patterns appeared serovar-dependent. • Serovar 4b-derived mutants showed greater fitness loss than 2a or 2b. • Phage-resistance induction led to increased antibiotics sensitivity.
Intratumoral bacterium Enterocloster bolteae promotes hepatocellular carcinoma progression by directly binding tumor cells
Highlights • E. bolteae is enriched in HCC patient feces and correlates with poor prognosis • E. bolteae translocates to the liver and promotes the progression of HCC • E. bolteae surface protein PbpT subverts DSG1 function, thereby activating MAPK signaling • Neutralizing antibodies against PbpT suppress tumor growth in murine models
Commensal enteric virome regulates intestinal carbohydrate digestion and absorption
Highlights • Virome functions as an independent regulator of small intestinal nutrient sensing • Virome elicits distinct responses across different intestinal cell types • Virome regulation of carbohydrate sensing depends on immune surveillance
Microbial SCFAs as epigenetic mediators: fine-tuning the gut-brain axis in neurodegenerative disorders
Highlights ● SCFAs function as gut-derived epigenetic regulators, bridging dietary fiber metabolism to brain-wide chromatin remodeling in neurodegenerative diseases. ● Butyrate acts as a potent HDAC inhibitor, enhancing histone acetylation to suppress neuroinflammation and promote synaptic plasticity in AD and PD models. ● SCFAs modulate DNA methylation dynamics via TET-DNMT balance, correcting aberrant gene expression linked to Aβ and α-synuclein pathologies. ● Emerging evidence positions histone lactylation as a novel SCFA-sensitive mechanism linking microglial metabolism to neuroinflammatory loops in neurodegeneration.