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Immune-microbiome coordination defines interferon setpoints in healthy humans

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  Highlights • Comprehensive multi-omic analysis of the immune system and microbiome in healthy humans • Major axes of immune variation are driven by interferon response signatures • Specific immune cell states are coordinated with microbiome pathways and metabolites • Coordinated immune and microbiome features are stable within individuals over time
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The complex interplay between hepatitis D virus and the interferon response

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  Highlights • HDV triggers innate immune sensing but largely escapes interferon-mediated control • Nuclear replication limits HDV exposure to antiviral interferon-stimulated genes • HDV selectively impairs IFN-α signaling through USP18-mediated negative feedback • Interferon efficacy against HDV varies across viral genotypes and cell models • Understanding HDV-IFN interactions is key to optimizing future combination therapies
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Early-life rotavirus infection susceptibility and later gastrointestinal cancer protection: Reverse antagonistic pleiotropy and potential vaccine benefits

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  Highlights • Whole-exome sequencing in severe rotavirus cases identified seven candidate SNPs, several linked to gastrointestinal cancer pathways. • Transcriptomic and epigenomic data supported functional involvement of top candidate genes and suggested roles in cancer progression. • Polygenic risk score analyses indicated reduced gastrointestinal cancer risk among individuals with severe early-life RV infection. • Evidence of recent positive selection in key SNPs supports a model of reverse antagonistic pleiotropy, suggesting early RV susceptibility may confer later-life cancer protection.
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Deltaviruses spread through a viral Trojan Horse

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  Highlights • Deltaviruses hitchhike within helper virus virions, using them as viral Trojan Horses • The Trojan Horse model is mandatory for productive herpesvirus-deltavirus associations • This mode of propagation favors deltavirus infectivity • Trojan Horse model warrants screening for extra-hepatic deltavirus infections in humans
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Cross-cohort meta-analysis reveals conserved gut microbiome signatures of insomnia

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  HIGHLIGHTS • Cross-cohort meta-analysis reveals reproducible gut microbiome signatures of insomnia • Eight conserved gut taxa are consistently associated with insomnia across studies • A small number of gut microbes drive most insomnia-associated functional shifts • The Burkholderia - Caballeronia-Paraburkholderia (BCP) complex drives key functions • Microbial metabolic changes may indirectly shape host immune and neural states
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Microbial metabolism of food allergens determines the severity of IgE-mediated anaphylaxis

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  Highlights • Human saliva and small intestine harbor peanut (PN) allergen-degrading bacteria • Microbes degrade immunodominant PN allergens, reducing IgE binding • Microbial PN metabolism alters allergen absorption, mast cell activity, and anaphylaxis • PN-degrading  Rothia  abundance is linked to higher PN threshold in patients
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Història de l'odontologia

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La   història dels tractaments dentals   es remunta a milers d'anys.   L'abast d'aquest article es limita a la   història   anterior a 1981.
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