How Phylogeny and Environment Shape Glycoside Hydrolase Multidomain Architecture

Phylogeny strongly constrains glycoside hydrolase multidomain architecture across bacterial genera, while environmental factors fine‑tune domain organization in cosmopolitan lineages. Analysis of 158k GH proteins using domain‑adjacency networks reveals conserved lineage‑specific patterns and highlights accessory domains as key drivers of microbial functional adaptation.


Read full article for free (open access):

https://www.sciencedirect.com/science/article/pii/S2666517426001148


glycoside hydrolase (GH) multidomain architectures are chiefly phylogeny‑driven, with environment fine‑tuning domain organization in key GH families.


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