Clostridium immunis Sugar Drives IL‑22–Dependent Immunometabolic Protection Against Obesity

Clostridium immunis protects mice from obesity by secreting a phosphocholine‑modified exopolysaccharide that lowers IL‑22 in the intestine and visceral fat, boosting metabolic activity in adipose tissue. Mutant studies show phosphocholine is essential. Humans with obesity show reduced phosphocholine‑gene abundance, highlighting a translatable strategy to reduce visceral fat.


Read full article at:

https://www.sciencedirect.com/science/article/pii/S1931312826003604#

Clostridium immunis sugar lowers IL‑22 to boost visceral fat burning and counter obesity.



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