SCFA‑Producing Gut Commensals as Regulators of Alzheimer’s Neuroinflammation

SCFA‑producing gut bacteria are depleted in Alzheimer’s disease, weakening microbiota‑gut‑brain axis control of neuroinflammation. SCFAs shape microglial and astrocytic states, suppress NLRP3 activation, and influence amyloid, tau, and synaptic integrity. The review evaluates dietary, probiotic, postbiotic, and FMT strategies and outlines biomarker‑guided, personalized therapeutic approaches.


Read full article for free (open access):

https://www.sciencedirect.com/science/article/pii/S2666517426001161

SCFA‑Producing Gut Commensals as Regulators of Alzheimer’s Neuroinflammation


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