Small Intestinal Metabolic Overgrowth Syndrome: A Metabolome-Driven Framework Beyond Small Intestinal Bacterial Overgrowth

This review challenges the traditional concept of small intestinal bacterial overgrowth by integrating clinical phenotypes with microbial metabolic signaling. Emerging evidence indicates that hydrogen-, methane-, and sulfide-associated overgrowth states are linked to distinct metabolic alterations involving bile acids, tryptophan metabolism, and short-chain fatty acids, influencing both symptoms and systemic disease outcomes.


Read full article for free (open access):

https://www.sciencedirect.com/science/article/pii/S2319417026001162


Illustration linking hydrogen, methane, and sulfide overgrowth phenotypes with metabolic pathways, systemic effects, and therapeutic targets.


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