Discovery and Genomic Characterization of Jumbo Phage AbIJP1 Against Carbapenem-Resistant Acinetobacter baumannii

Researchers isolated AbIJP1, the largest known bacteriophage reported against Acinetobacter baumannii, from hospital sewage. This jumbo phage efficiently infected carbapenem-resistant clinical isolates, reduced biofilms, remained stable across clinically relevant conditions, and lacked lysogenic, virulence, or antibiotic resistance genes. Genomic analysis showed it is highly distinct from known phages and likely represents a new genus.


Read full article for free (open access):

https://www.sciencedirect.com/science/article/pii/S2666517426001380


Transmission electron microscopy image of jumbo phage AbIJP1 showing an icosahedral capsid and long contractile tail characteristic of Caudoviricetes.


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