Cellular Membranes as Battlegrounds: How Interferon Responses and Viruses Compete for Control of Membrane Biology

Cellular membranes lie at the center of the conflict between viruses and host defenses. This review explores how interferon-driven responses reshape lipid metabolism, membrane properties, intracellular trafficking, and organelle organization to restrict viral replication. It also examines how positive-strand RNA viruses remodel membranes and lipid networks to maintain replication-permissive environments.


Read full article for free (open access):

https://www.sciencedirect.com/science/article/pii/S2319417026001149


Schematic showing cellular membranes as contested territories where interferon-induced host defenses and viral membrane remodeling compete to control lipid metabolism, intracellular trafficking, replication organelles, viral entry, replication, assembly, and release.


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