MtrA Fine-Tunes Nitrogen Metabolism in Mycobacterium smegmatis Through Dual Regulation of the GlnR Nitrogen Network

Nitrogen availability is critical for mycobacterial survival, yet its regulation remains incompletely understood. This study identifies the response regulator MtrA as a key modulator of the GlnR-controlled nitrogen regulon in Mycobacterium smegmatis. Transcriptomic, biochemical, and physiological analyses showed that MtrA both activates and represses distinct gene sets, helping coordinate nutrient use and metabolic balance.


Read full article for free (open access):

https://www.sciencedirect.com/science/article/pii/S2666517426001264


Model of MtrA and GlnR regulatory interactions in Mycobacterium smegmatis, showing activation of amino acid catabolism genes, repression of selected nitrogen transport systems, distinct DNA-binding mechanisms, and effects on nitrogen metabolism under nutrient-limiting conditions.


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