Lung Microbiota and Chronic Obstructive Pulmonary Disease: Ecological Dysbiosis, Host Interactions, and Disease Progression

The lung microbiota is a dynamic ecosystem whose balance is disrupted in chronic obstructive pulmonary disease. This review explores how changes in microbial community structure, function, and stability influence airway inflammation, immune responses, and disease progression. It highlights dysbiosis, host-microbe interactions, the gut-lung axis, emerging biomarkers, and microbiota-based therapeutic strategies.


Read full article for free (open access):

https://www.sciencedirect.com/science/article/pii/S2666517426001355


Conceptual diagram showing the transition from a healthy, stable lung microbiota to dysbiosis in chronic obstructive pulmonary disease, illustrating microbial imbalance, host immune and epithelial interactions, pathobiont expansion, inflammation, the gut-lung axis, and a self-perpetuating cycle of disease progression.


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