How Insoluble Dietary Fiber Reduces Colorectal Cancer Risk by Suppressing Gut Microbiota-Derived GM3

Researchers found that insoluble dietary fiber slows colorectal cancer progression in mice by altering gut microbiota and reducing production of the tumor-promoting ganglioside GM3. Fiber lowered levels of Paramuribaculum intestinale and a glycosphingolipid-related microbial enzyme, while GM3 was shown to stimulate tumor growth and inhibit cancer cell apoptosis.



Read full article for free (open access):

https://www.sciencedirect.com/science/article/pii/S2666517426000258




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