Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures

Highlights

•
A proteomic blueprint of human organs across 50-year aging stages
•
Transcriptome-proteome decoupling and proteostasis failure mark aged tissues
•
Human organ proteomic clocks reveal aging inflection and asynchrony
•
Circulating senoproteins contribute to vascular and systemic aging


Summary

Proteins are the cornerstone of life. However, the proteomic blueprint of aging across human tissues remains uncharted. Here, we present a comprehensive proteomic and histological analysis of 516 samples from 13 human tissues spanning five decades. This dynamic atlas reveals widespread transcriptome-proteome decoupling and proteostasis decline, characterized by amyloid accumulation. Based on aging-associated protein changes, we developed tissue-specific proteomic age clocks and characterized organ-level aging trajectories. Temporal analysis revealed an aging inflection around age 50, with blood vessels being a tissue that ages early and is markedly susceptible to aging. We further defined a plasma proteomic signature of aging that matches its tissue origins and identified candidate senoproteins, including GAS6, driving vascular and systemic aging. Together, our findings lay the groundwork for a systems-level understanding of human aging through the lens of proteins.

Article in Cell. Read more at:
https://www.cell.com/cell/abstract/S0092-8674(25)00749-4



Popular posts from this blog

David M. Ojcius, PhD - Editorial Board - Journals | Elsevier

Image
David Ojcius is Professor at the University of the Pacific in San Francisco, USA. He gained his Ph.D. from the University of California, Berkeley, and did research at Rockefeller and Harvard before moving to the Pasteur Institute in Paris, France, where he worked for thirteen years. His research interests include viruses and intracellular bacteria, interactions with the innate immune system, microbiota, biochemistry and cell biology of infected cells, inflammation and aging. https://www.journals.elsevier.com/current-research-in-microbial-sciences/editorial-board/david-m-ojcius-phd
Read more

Dugoni faculty member will fight oral cancer with $700K NIH award

Image
Xiaoyuan Han, an assistant professor in the Arthur A. Dugoni School of Dentistry at University of the Pacific, has received a prestigious National Institutes of Health grant for $702,000 to study oral cancer using artificial intelligence tools. Han, who teaches in the Department of Biomedical Sciences, was awarded a Support for Research Excellence-First Independent Research Award for four years. “Dr. Han’s work could help identify patients needing early care and increase our ability to provide personalized medical care to treat these patients,” said David Ojcius, assistant dean for research and co-chair of the Department of Biomedical Sciences. The award will provide opportunities for predental and predoctoral dental students to participate in research and collaborate with a multidisciplinary team to improve oral pathology diagnosis, Han said.
Read more