RNA Structures Control Norovirus Replication and Enable Rational Attenuation In Vivo

Structured RNA elements across the norovirus genome were mapped and functionally tested, revealing conserved motifs that regulate replication and translation. Disrupting key structures reduced viral fitness in cells and animals, enabling design of a stable attenuated virus that elicits protective immunity and supports RNA‑guided antiviral strategies.


Read full article for free (open access):

https://www.sciencedirect.com/science/article/pii/S0092867426009207


Conserved #norovirus RNA structures control replication & #immunity, enabling design of a stable, protective attenuated virus.

Conserved norovirus RNA structures control replication & immunity, enabling design of a stable, protective attenuated virus.

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