Mineralo-organic particles inhibit influenza A virus infection by targeting viral hemagglutinin activity

 Abstract

Aim: Mineralo-organic particles, naturally present in human body fluids, participate in ectopic calcification and inflammatory diseases. These particles coexist with influenza A virus (IAV) in the same microenvironment during viral infection. Our objective was to investigate the functional consequences of the potential interactions between these particles and the virions.

Materials & methods: We used in vitro models, including electron microscopy, fluorescence microscopy, hemagglutination assay and viral infection assays to examine the interactions.

Results: Mineralo-organic particles bind to IAV virions through interactions involving particle-bound fetuin-A and mineral content, effectively engaging viral hemagglutinin. These interactions result in hindered viral infection.

Conclusion: These findings uncover the novel interactions between mineralo-organic particles and IAV, highlighting the impact of virus microenvironment complexity.


https://www.tandfonline.com/doi/full/10.1080/17435889.2024.2403326?scroll=top&needAccess=true


https://pubmed.ncbi.nlm.nih.gov/39320315/



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David Ojcius is Professor at the University of the Pacific in San Francisco, USA. He gained his Ph.D. from the University of California, Berkeley, and did research at Rockefeller and Harvard before moving to the Pasteur Institute in Paris, France, where he worked for thirteen years. His research interests include viruses and intracellular bacteria, interactions with the innate immune system, microbiota, biochemistry and cell biology of infected cells, inflammation and aging. https://www.journals.elsevier.com/current-research-in-microbial-sciences/editorial-board/david-m-ojcius-phd
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