Metformin decelerates aging clock in male monkeys

Highlights

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Metformin prevents brain atrophy, elevating cognitive function in aged male primates
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Metformin slows the pace of aging across diverse male primate tissues
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Metformin counterparts neuronal aging, delivering geroprotection via Nrf2 in male primates

 

Summary

In a rigorous 40-month study, we evaluated the geroprotective effects of metformin on adult male cynomolgus monkeys, addressing a gap in primate aging research. The study encompassed a comprehensive suite of physiological, imaging, histological, and molecular evaluations, substantiating metformin’s influence on delaying age-related phenotypes at the organismal level. Specifically, we leveraged pan-tissue transcriptomics, DNA methylomics, plasma proteomics, and metabolomics to develop innovative monkey aging clocks and applied these to gauge metformin’s effects on aging. The results highlighted a significant slowing of aging indicators, notably a roughly 6-year regression in brain aging. Metformin exerts a substantial neuroprotective effect, preserving brain structure and enhancing cognitive ability. The geroprotective effects on primate neurons were partially mediated by the activation of Nrf2, a transcription factor with anti-oxidative capabilities. Our research pioneers the systemic reduction of multi-dimensional biological age in primates through metformin, paving the way for advancing pharmaceutical strategies against human aging.


Read full article at:

https://www.cell.com/cell/abstract/S0092-8674(24)00914-0?dgcid=raven_jbs_aip_email




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David Ojcius is Professor at the University of the Pacific in San Francisco, USA. He gained his Ph.D. from the University of California, Berkeley, and did research at Rockefeller and Harvard before moving to the Pasteur Institute in Paris, France, where he worked for thirteen years. His research interests include viruses and intracellular bacteria, interactions with the innate immune system, microbiota, biochemistry and cell biology of infected cells, inflammation and aging. https://www.journals.elsevier.com/current-research-in-microbial-sciences/editorial-board/david-m-ojcius-phd
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