The oral microbiome is a complex community of bacteria, fungi, and viruses that inhabit the oral cavity. Microbes of the oral microbiome are implicated in health and disease. We collected 220 unstimulated saliva samples from patients with periodontal disease and varying degrees of dental caries, as well as from subjects with no signs of oral disease. Metagenomic analysis of saliva revealed significantly higher abundance of periodontal pathogens in people with gum disease, and significantly higher abundance of cariogenic species in people with dental caries. We also found that salivary microbiome diversity was significantly higher in people with periodontal disease, but not in those with only caries. Furthermore, oral microbiome diversity is affected by oral hygiene habits such as flossing frequency, but not brushing frequency. Clustering and differential analysis allowed us to identify specific commensal species, such as Prevotella pallens and Veillonella atypica , which are signi...
Highlights • Ketogenic diet (KD) alleviates sepsis-induced lung injury via the gut microbiota • KD-enriched lactobacilli produce azelaic acid (AZA) that migrates to sepsis lung • Lung AZA induces MerTK + macrophages via PPAR-γ toward efferocytosis • AZA associates with improved clinical outcomes in patients with sepsis
University of the Pacific secured 62 grants from federal, state and county agencies totaling more than $36 million—one of the best years for government grants in school history. The dramatic increase in fiscal year 2023—double the amount awarded to Pacific in 2022—was largely driven by three of the university’s largest grants, which include $6 million for the School of Health Sciences to expand the social work program , $5.6 million for Benerd College to support mental health services in K-12 schools and $5 million to McGeorge School of Law to improve mental health services in California . This was the best year for grants at Pacific in 15 years. “This is a reflection of the exceptional work our faculty are doing to address pressing issues,” said David Ojcius, assistant provost for research and scholarship. “These grants will have a significant impact on the community.” Read full article at: https://www.pacific.edu/pacific-newsroom/pacific-has-on...
