Mostly Microbes and Infection

  Highlights • Deltaviruses hitchhike within helper virus virions, using them as viral Trojan Horses • The Trojan Horse model is mandatory for productive herpesvirus-deltavirus associations • This mode of propagation favors deltavirus infectivity • Trojan Horse model warrants screening for extra-hepatic deltavirus infections in humans

  HIGHLIGHTS • Cross-cohort meta-analysis reveals reproducible gut microbiome signatures of insomnia • Eight conserved gut taxa are consistently associated with insomnia across studies • A small number of gut microbes drive most insomnia-associated functional shifts • The Burkholderia - Caballeronia-Paraburkholderia (BCP) complex drives key functions • Microbial metabolic changes may indirectly shape host immune and neural states

  Highlights • Human saliva and small intestine harbor peanut (PN) allergen-degrading bacteria • Microbes degrade immunodominant PN allergens, reducing IgE binding • Microbial PN metabolism alters allergen absorption, mast cell activity, and anaphylaxis • PN-degrading  Rothia  abundance is linked to higher PN threshold in patients

La   història dels tractaments dentals   es remunta a milers d'anys.   L'abast d'aquest article es limita a la   història   anterior a 1981.

  Highlights • Bacteria trigger extracellular alkalinization to prime defenses in uninfected tissues • CPKs phosphorylate and inhibit plasma membrane proton pumps to induce alkalinization • Alkaline pH sensitizes perception and production of the phytocytokines Peps and SCOOPs • Phytocytokines and alkalinization jointly propagate to promote cell-cell communication

  Highlights • Dietary variables had the largest effect on microbiota composition • Rustic and conventional rearing conditions led to differential microbiota profiles • Rustic rearing favoured  Treponema -enriched, more-diverse microbial profiles • Enterotypes were associated with husbandry conditions and faecal water content • Underexplored taxa contributed to  in vitro  fibre fermentation and SCFA production

  Highlights • Most mutations occurred in genes associated with WTA glycosylation. • All mutants exhibited impaired P100 phage binding. • Gene mutation patterns appeared serovar-dependent. • Serovar 4b-derived mutants showed greater fitness loss than 2a or 2b. • Phage-resistance induction led to increased antibiotics sensitivity.