Mostly Microbes and Infection

Parabacteroides   is a   Gram-negative ,   anaerobic , non- spore -forming genus from the family   Tannerellaceae . First isolated from fecal specimen in 1933, type strain  Parabacteroides distasonis  was originally classified under the name  Bacteroides distasonis.  The strain was re-classified to form the new genus  Parabacteroides  in 2006.  Parabacteroides  currently comprise 21 phylogenetically, ecologically, and metabolically diverse species, 11 of which are listed in the taxonomic database 

  Highlights • Bacillus  sp. HC-9 controls honeysuckle leaf spot caused by  A. alternata. • Strain HC-9 inhibits eight phytopathogenic fungi with strong antifungal activity. • Strain HC-9 induces ROS and activates defense enzymes in honeysuckle leaves. • Field trials show HC-9 achieves up to 80.52% disease control efficiency.

  Highlights • Identification of the TamA protein as a highly conserved antigen across diverse  Klebsiella pneumoniae  strains, making it an ideal target for a broad-spectrum subunit vaccine. • Development and evaluation of a recombinant TamA protein vaccine that significantly enhances immune protection against a highly virulent  Klebsiella pneumoniae  infection in a murine model. • Demonstration of TamA-induced specific antibodies that effectively inhibit bacterial adherence to epithelial cells, thereby reducing bacterial load and pathological damage in vaccinated mice. • Significant survival benefit observed in TamA-vaccinated mice, with 80 % surviving over 10 days following a lethal dose challenge, compared to controls that survived less than 48 h. • Reduction in tissue bacterial loads and cytokine levels, along with mitigation of pathological changes in TamA-immunized mice, supporting the potential of TamA as a candidate vaccine for preventing  Klebsiel...

Chlamydiosen   sind durch verschiedene   Chlamydien   (bestimmte   Bakterienarten ) verursachte   Infektionskrankheiten . Sie betreffen das   Auge   (als   Trachom ), die   Atemwege   und die   Lunge   (als   Pneumonie ) und den   Urogenitaltrakt   (Harn- und Geschlechtsorgane) als   sexuell übertragene Krankheit .

  Highlights • Phospholipid diversity shapes membrane properties for growth and stress adaptation • Bacteria remodel phospholipid head groups and acyl chains to resist antimicrobials • Phospholipid and its metabolism serve as promising potential antibacterial targets

  Highlights • First systematic report of  Niallia taxi  BN5 with plant growth-promoting (PGP) activity, filling the  Niallia  PGP mechanism gap (previously studied for bioremediation/antibacterial functions). • Multi-omics (genome/transcriptome/qPCR) show BN5 has a complete trp operon for constitutive IAA biosynthesis (17.64 μg/mL); tryptophan regulates trp/motility genes. • BN5 enhances cucumber growth (height +24.29%, stem +11.23%), yield (+17.55%) and quality (vitamin C +17.2%, soluble sugar +37.41%) in pot/greenhouse trials. • BN5 reshapes rhizosphere microbiomes (enriches  Bacillus / Pseudomonas ) and elevates soil enzymes, providing a microbial resource for sustainable agriculture.

Many shots seem to have “off-target” benefits, such as lowering the risk of dementia, studies have found.

  Highlights • Distinct microbial communities are found in peritoneal dialysis (PD) and paired hemodialysis (HD) patients, despite similar microbiome diversity. • Serum p-cresyl sulfate (PCS) levels are significantly lower in PD patients compared to paired HD patients. • Altered microbial composition in PD patients, featuring more opportunistic pathogens and fewer beneficial bacteria, is linked to differences in metabolite profiles. • Fecal transplant experiments confirm that the HD-associated gut microbiota directly leads to higher PCS production. • Targeting the gut microbiota presents a potential therapeutic strategy to reduce uremic toxins in dialysis patients.

  Highlights • Salinity and nutrient availability affect the utilization and secretion of amino acids by deep biosphere microbial consortia • Anoxic deep biosphere enrichment cultures were compared to Desulfovibrio desulfuricans • Amino acids and organic acids were degraded under different nutrient conditions • Phe and Val degradation remained unaffected by changes in nutrient availability • Metabolic pathways involving Phe, Cys and Met were most prominent

  Highlights • Mixed reed and willow vegetation boosts denitrification more than monocultures. • nirK  denitrifiers are major drivers of N removal variation over  nirS . • Soil depth reshapes denitrifiers:  nirS  depth-sensitive,  nirK  nutrient-responsive. • Reed-willow boosts network complexity with depth to foster microbial interactions. • Bradyrhizobium, Sinorhizobiu m, and  Mesorhizobium  are key to mitigating N loss.

  Highlights • Pseudomonas, Escherichia and Prevotella dominated DFU assemblage across visits • Alcaligenes dominated healed DFU while Enterococcus was abundant in worsened DFU • High HbA1c favored Pseudomonas while Prevotella was abundant in lower HbA1c samples • Amputated DFUs had increased abundance of Escherichia and reduced Staphylococcus • Microbiome functional profiles in worsened DFU were enriched in virulence factors

  Highlights • Butyrolactol A synergizes with caspofungin against cryptococci and  Candida auris • BLA restores echinocandin efficacy by targeting the Apt1-Cdc50 flippase complex • Cryo-EM shows BLA traps the Apt1-Cdc50 phospholipid flippase in a dead-end state • BLA blocks lipid transport, disrupts membrane homeostasis, and boosts drug uptake

  Highlights • Viruses are largely overlooked in outdoor aeromicrobiological studies • Based on current knowledge in aeromicrobiology, a total of 10 21  virus particles are estimated to occupy clouds globally • Although very dilute, these may contribute to the atmospheric life cycle of microorganisms • Virus-bacteria interactions in clouds would have many implications in ecology and the Earth’s microbiome