Mostly Microbes and Infection

  Introduction: Boswellia trees are the source of frankincense extracts that can be found throughout the Middle East and parts of Africa and Asia. Although frankincense is a precious commodity for trading, it is also used as a traditional medicine for sustainable, cost-effective therapeutic purposes. The bioactive components of the extract have been identified and characterized to have diverse effects on cancer, microbial infections, and inflammation. However, the potential antimicrobial effects of frankincense extracts on oral bacteria are still to be elucidated.

Smoking increases the risk of heart disease, cancer, lung infections, and diabetes, and causes oral health problems. The prevalence of smoking is significantly influenced by intersecting factors such as socioeconomic status, racial and ethnic marginalization, and differing cultural practices. Importantly, minority groups experience earlier tobacco exposure and reduced access to education and cessation programs. A comprehensive analysis of individual characteristics is essential for predicting and effectively addressing tobacco-related oral and systemic health disparities. Education and prevention initiatives are key to decreasing the prevalence of smoking in populations affected by structural inequities.  

Cette composante s’est appuyée sur la méthodologie développée par l’association RESOLIS, à savoir une méthode d’analyse systématique et raisonnée des projets de transitions écologiques, sanitaires, sociales et agronomiques et de leur impact transformatif. L’analyse repose sur les fiches RESOLIS élaborées par les membres du consortium dans le cadre de l’Observatoire.  

Highlights • P .  gingivalis  upregulated P2X7 receptor levels in the colon of wildtype mice. • P .  gingivalis  triggered intestinal inflammation in wildtype mice but not in P2X7-deficient mice. • The  P .  gingivalis -induced liver alterations were reduced in P2X7-deficient mice. • P .  gingivalis  modulates the balance of T reg  and Th17 cells in wildtype mice. • Oral ingestion of  P .  gingivalis  increases the translocation of gut bacteria to the liver of wildtype mice.

On the occasion of the high-level meeting showcasing 130 years of Science at the Institut Pasteur, the Genes & Immunity Journal published a special issue reporting the presentations that had been given. A collection of articles that highlights the Institut Pasteur’s 130 years of involvement in studying infectious diseases and fighting for public health.

La revue  Genes & Immunity  publie, à l’occasion de la rencontre au sommet célébrant 130 ans de recherche à l’Institut Pasteur, un numéro spécial retraçant les études phares qui y ont été menées. Ce numéro rassemble des articles mettant en lumière les 130 années d’engagement de l’Institut Pasteur dans l’étude des maladies infectieuses et la lutte pour la santé publique.