Mostly Microbes and Infection

Highlights • Extracellular nucleotides are key actors of cell signalling through P2 receptors • Dysregulated vesicle release is implicated in immune diseases and cancer • P2 receptors emerge as a mechanism controlling micro- and nano-vesicle release  

Highlights • Obelisks are a phylogenetically distinct group of microbiome-associated, viroid-like RNAs • Found globally in diverse niches, obelisks also occur in human stool and oral microbiomes • The human oral bacterium  Streptococcus sanguinis  SK36 harbors a distinct “obelisk- S.s ” • Under replete growth conditions, obelisk- S.s  appears to be disposable for SK36 growth