Mostly Microbes and Infection

  Highlights • Bacillus  sp. HC-9 controls honeysuckle leaf spot caused by  A. alternata. • Strain HC-9 inhibits eight phytopathogenic fungi with strong antifungal activity. • Strain HC-9 induces ROS and activates defense enzymes in honeysuckle leaves. • Field trials show HC-9 achieves up to 80.52% disease control efficiency.

  Highlights • Identification of the TamA protein as a highly conserved antigen across diverse  Klebsiella pneumoniae  strains, making it an ideal target for a broad-spectrum subunit vaccine. • Development and evaluation of a recombinant TamA protein vaccine that significantly enhances immune protection against a highly virulent  Klebsiella pneumoniae  infection in a murine model. • Demonstration of TamA-induced specific antibodies that effectively inhibit bacterial adherence to epithelial cells, thereby reducing bacterial load and pathological damage in vaccinated mice. • Significant survival benefit observed in TamA-vaccinated mice, with 80 % surviving over 10 days following a lethal dose challenge, compared to controls that survived less than 48 h. • Reduction in tissue bacterial loads and cytokine levels, along with mitigation of pathological changes in TamA-immunized mice, supporting the potential of TamA as a candidate vaccine for preventing  Klebsiel...

Chlamydiosen   sind durch verschiedene   Chlamydien   (bestimmte   Bakterienarten ) verursachte   Infektionskrankheiten . Sie betreffen das   Auge   (als   Trachom ), die   Atemwege   und die   Lunge   (als   Pneumonie ) und den   Urogenitaltrakt   (Harn- und Geschlechtsorgane) als   sexuell übertragene Krankheit .

  Highlights • Phospholipid diversity shapes membrane properties for growth and stress adaptation • Bacteria remodel phospholipid head groups and acyl chains to resist antimicrobials • Phospholipid and its metabolism serve as promising potential antibacterial targets

  Highlights • First systematic report of  Niallia taxi  BN5 with plant growth-promoting (PGP) activity, filling the  Niallia  PGP mechanism gap (previously studied for bioremediation/antibacterial functions). • Multi-omics (genome/transcriptome/qPCR) show BN5 has a complete trp operon for constitutive IAA biosynthesis (17.64 μg/mL); tryptophan regulates trp/motility genes. • BN5 enhances cucumber growth (height +24.29%, stem +11.23%), yield (+17.55%) and quality (vitamin C +17.2%, soluble sugar +37.41%) in pot/greenhouse trials. • BN5 reshapes rhizosphere microbiomes (enriches  Bacillus / Pseudomonas ) and elevates soil enzymes, providing a microbial resource for sustainable agriculture.

Many shots seem to have “off-target” benefits, such as lowering the risk of dementia, studies have found.